/* Notebook: a visual index and quiet, standalone reading pages. */
.nb-heading{padding:25px 32px;border-bottom:1px solid var(--line);display:flex;align-items:baseline;justify-content:space-between;gap:24px}
.nb-heading h2{font-size:24px;font-weight:500;letter-spacing:-.025em}
.nb-heading p{font-size:14px}
.nb-group+.nb-group{border-top:1px solid var(--line)}
.nb-group-tissue>.nb-heading{background:#e9eee5}
.nb-group-delivery>.nb-heading{background:#eee5d8}
.nb-group-regulation>.nb-heading{background:#f0ece5}
.paper-meta .paper-area{color:#617563}
.nb-entry{display:grid;grid-template-columns:168px minmax(0,1fr) minmax(240px,340px);gap:32px;padding:32px;align-items:center;border-bottom:1px solid var(--line);color:var(--ink)}
.nb-entry:last-child{border-bottom:0}.nb-date{font:11px/1.8 var(--mono);color:var(--muted);align-self:start;padding-top:7px}
.nb-type{font:10px/1.6 var(--mono);letter-spacing:.08em;text-transform:uppercase;color:var(--muted)}
.nb-entry h3{font-size:clamp(25px,2.1vw,34px);font-weight:500;line-height:1.14;letter-spacing:-.035em;margin:16px 0 14px;max-width:26ch}
.nb-entry h3 span{font-size:25px;font-weight:400;color:var(--blue);white-space:nowrap;margin-left:10px}
.nb-entry p{font-size:16px;line-height:1.6;max-width:53ch}.nb-entry:hover h3{color:var(--blue)}
.nb-entry:focus-visible{outline-offset:-5px}.nb-thumb{margin:0;align-self:stretch;min-height:172px;display:flex;align-items:center;justify-content:center}
.nb-thumb img{display:block;width:100%;height:190px;object-fit:contain;transition:transform .25s ease}
.nb-entry:hover .nb-thumb img{transform:translateY(-3px)}
.nb-methods{border-top:1px solid var(--line)}.nb-methods .nb-entry{grid-template-columns:minmax(0,1fr) minmax(240px,340px);padding:28px 32px;gap:40px}.nb-methods .nb-thumb img{height:170px}
.nb-methods .nb-entry h3{font-size:28px;margin-top:0}.nb-methods .nb-entry p{font-size:15px}
.nb-methods .nb-heading{padding-top:38px;padding-bottom:27px}
.nb-tail{padding:26px 32px;border-top:1px solid var(--line);font-size:14px;line-height:1.65;color:var(--muted)}
.nb-tail a{color:var(--blue);text-decoration:underline;text-underline-offset:3px}
.paper-back{padding:22px 32px;border-bottom:1px solid var(--line);display:flex;justify-content:space-between;gap:24px;font:11px/1.5 var(--mono);color:var(--muted)}
.paper-back a{color:var(--blue)}.paper-header{max-width:1024px;margin:0 auto;padding:44px 32px 38px;display:block;width:100%}
.paper-meta{font:11px/1.9 var(--mono);color:var(--muted);display:flex;gap:24px;margin-bottom:26px;flex-wrap:wrap}.paper-meta span{display:block;margin:0}
.paper-header h1{font-size:clamp(42px,4.3vw,67px);line-height:1.03;letter-spacing:-.045em;font-weight:600;max-width:24ch;text-wrap:balance}
.paper-deck{font-size:20px;line-height:1.5;max-width:58ch;margin-top:24px}.paper-state{font:10px/1.7 var(--mono);letter-spacing:.06em;text-transform:uppercase;display:block;margin-top:26px;color:var(--muted)}
.paper-body{display:block;padding:0 32px 60px}
.paper-toc{display:flex;flex-wrap:wrap;align-items:center;gap:13px 25px;padding:22px 0;margin:0 auto;border-top:1px solid var(--line);border-bottom:1px solid var(--line);max-width:960px;font:13px/1.5 IBM Plex Sans,sans-serif;color:var(--muted)}.paper-toc .contents-label{flex-basis:100%;font:10px/1.5 var(--mono);letter-spacing:.05em;margin-bottom:2px}.paper-toc a{white-space:nowrap}
.paper-toc a:hover{color:var(--blue)}.paper-main{min-width:0;max-width:960px;margin:0 auto;padding-top:38px}
.paper-main section{scroll-margin-top:25px}.paper-main h2{font-size:30px;font-weight:500;line-height:1.16;letter-spacing:-.025em;margin:49px 0 23px;max-width:28ch}
.paper-main section:first-child h2{margin-top:0}
.paper-main p,.paper-main li{font-family:IBM Plex Sans,Arial,sans-serif;font-size:19px;line-height:1.75;color:var(--ink);max-width:69ch}
.paper-main p+p{margin-top:20px}.paper-main ul,.paper-main ol{max-width:72ch;padding-left:23px;margin:22px 0}.paper-main li+li{margin-top:12px}
.paper-main p a,.paper-refs a{color:var(--blue);text-decoration:underline;text-underline-offset:4px}
.paper-figure{margin:32px 0 38px}.paper-figure>a{display:block;background:#fff}.paper-figure img{display:block;width:100%;max-height:700px;object-fit:contain}
.paper-figure figcaption{display:grid;grid-template-columns:76px minmax(0,1fr);gap:16px;border-top:1px solid var(--line);padding:18px 0 0;font:13px/1.65 'IBM Plex Sans',sans-serif;color:var(--muted)}
.paper-figure figcaption b{font:10px/1.7 var(--mono);color:var(--blue);letter-spacing:.04em}.paper-figure .figure-open{display:block;margin-top:8px;color:var(--blue);font:10px/1.5 var(--mono);text-decoration:none}
.paper-summary{border-left:2px solid var(--blue);padding:0 0 0 23px;margin:28px 0}.paper-summary p{font-family:'IBM Plex Sans',sans-serif;font-size:18px;line-height:1.6;color:var(--ink)}
.paper-table-scroll{overflow-x:auto;margin:28px 0}.paper-table{border-collapse:collapse;width:100%;font-size:14px;line-height:1.5;min-width:480px}
.paper-table th{font:10px/1.6 var(--mono);letter-spacing:.04em;text-transform:uppercase;color:var(--muted);text-align:left;padding:14px 16px 14px 0;border-bottom:1px solid var(--line)}
.paper-table td{padding:16px 16px 16px 0;border-bottom:1px solid var(--line);font-variant-numeric:tabular-nums}.paper-table td:last-child{padding-right:0}
.paper-files{margin-top:25px;border-top:1px solid var(--line)}.paper-files a{display:grid;grid-template-columns:minmax(0,1fr) auto;gap:16px;padding:20px 0;border-bottom:1px solid var(--line);align-items:center}
.paper-files strong{font-size:16px;font-weight:500}.paper-files small{display:block;margin-top:6px;font-size:13px;line-height:1.55;color:var(--muted);max-width:65ch}.paper-files .file-format{font:10px var(--mono);color:var(--blue);white-space:nowrap}
.paper-main .paper-refs{font:13px/1.8 'IBM Plex Sans',sans-serif;padding-left:18px}.paper-refs li{font:13px/1.8 'IBM Plex Sans',sans-serif;max-width:85ch;color:var(--muted)}
.paper-main .paper-disclosure{font:12px/1.75 'IBM Plex Sans',sans-serif;color:var(--muted);border-top:1px solid var(--line);padding-top:22px;margin-top:38px;max-width:90ch}
.paper-next{border-top:1px solid var(--line);display:flex;justify-content:space-between;gap:28px;padding:30px 32px;font-size:18px}.paper-next a{color:var(--blue)}
.paper-culture{margin:30px 0}.paper-culture .tc-toolbar{display:none}.paper-culture .tc-sequence{border-bottom:1px solid var(--line)}.paper-culture .figure-key{font-size:10px}.paper-culture .tc-canvas{min-height:0}
.paper-equations{display:grid;grid-template-columns:repeat(3,minmax(0,1fr));margin:30px 0;border-top:1px solid var(--line);border-bottom:1px solid var(--line)}
.paper-equations>div{padding:24px 18px 24px 0}.paper-equations span{font:10px var(--mono);color:var(--muted);text-transform:uppercase;letter-spacing:.06em}.paper-equations strong{display:block;font-size:24px;font-weight:500;letter-spacing:-.03em;margin:16px 0 10px}.paper-equations small{font-size:13px;line-height:1.6;color:var(--muted)}

@media(max-width:1100px){.nb-entry{grid-template-columns:108px minmax(0,1fr) 260px;gap:24px}.nb-thumb img{height:170px}.nb-methods .nb-entry{grid-template-columns:minmax(0,1fr) 260px}.paper-header h1{font-size:52px}.nb-entry h3{font-size:28px}}
@media(max-width:800px){.nb-entry{grid-template-columns:1fr 230px;gap:20px;padding:28px 24px}.nb-date{grid-column:1/-1;padding:0}.nb-entry h3{font-size:26px;margin-top:12px}.nb-entry p{font-size:15px}.nb-thumb img{height:165px}.nb-heading{padding:23px 24px}.nb-methods .nb-entry{grid-template-columns:minmax(0,1fr) 230px;padding-left:24px;gap:24px}.paper-header{display:block;padding:34px 24px}.paper-meta{display:flex;gap:20px;margin-bottom:26px;flex-wrap:wrap}.paper-meta span{margin:0;max-width:none}.paper-header h1{font-size:47px}.paper-body{display:block;padding:0 24px 40px}.paper-toc{gap:12px 22px}.paper-main{padding-top:30px}.paper-main p,.paper-main li{font-size:18px}.paper-back,.paper-next{padding:22px 24px}}
@media(max-width:550px){.nb-entry{grid-template-columns:1fr;padding:27px 20px 30px;gap:12px}.nb-date{grid-column:1;font-size:10px}.nb-type{font-size:9px}.nb-entry h3{font-size:29px;max-width:26ch;margin:13px 0}.nb-entry p{font-size:15px}.nb-thumb{min-height:0;margin-top:9px;justify-content:flex-start}.nb-thumb img{height:180px;max-width:380px;object-position:left center}.nb-methods .nb-thumb img{height:170px}.nb-heading{display:block;padding:25px 20px}.nb-heading h2{font-size:22px}.nb-heading p{margin-top:10px}.nb-methods .nb-heading{padding:29px 20px}.nb-methods .nb-entry{grid-template-columns:1fr;padding:26px 20px;gap:12px}.nb-tail{padding:24px 20px}.paper-back{padding:20px;font-size:10px}.paper-back>span{display:none}.paper-header{padding:28px 20px 32px}.paper-meta{font-size:10px;gap:6px 20px;line-height:1.6}.paper-header h1{font-size:39px;line-height:1.07}.paper-deck{font-size:17px;margin-top:20px}.paper-state{font-size:9px}.paper-body{padding:0 20px 35px}.paper-toc{font-size:12px;gap:12px 20px}.paper-main h2{font-size:28px;margin-top:39px}.paper-main p,.paper-main li{font-size:17px;line-height:1.75}.paper-figure{margin:27px -8px}.paper-figure figcaption{grid-template-columns:1fr;gap:5px;font-size:12px;padding-left:8px;padding-right:8px}.paper-files strong{font-size:15px}.paper-files a{gap:12px}.paper-files .file-format{font-size:9px}.paper-equations{grid-template-columns:1fr}.paper-equations>div{padding:20px 0}.paper-equations>div+div{border-top:1px solid var(--line)}.paper-equations strong{font-size:26px;margin-top:12px}.paper-next{padding:25px 20px;font-size:16px}.paper-summary{padding-left:17px}.paper-summary p{font-size:17px}}
@media(prefers-reduced-motion:reduce){.nb-thumb img{transition:none}.nb-entry:hover .nb-thumb img{transform:none}}
@media print{.site-header,.site-footer,.paper-back,.paper-toc,.paper-next,.paper-files,.paper-state,.figure-open{display:none!important}.page-frame{margin:0;border:0}.paper-header,.paper-body{display:block;padding:0;border:0}.paper-header h1{font-size:30pt;max-width:none}.paper-meta{margin-bottom:20px}.paper-main{max-width:none}.paper-main p,.paper-main li{font-size:11pt}.paper-main h2{font-size:19pt}.paper-figure{break-inside:avoid}.paper-figure img{max-height:155mm}.paper-figure figcaption{font-size:9pt}a{color:inherit}}

.paper-meta .paper-date{margin-top:0}
.paper-main h3{font-size:20px;line-height:1.4;font-weight:500;letter-spacing:-.015em;margin:32px 0 14px;max-width:50ch}.paper-main table+p{margin-top:24px}
.paper-workflow{margin:32px 0 38px;border-top:1px solid var(--line);border-bottom:1px solid var(--line);padding:28px 0 22px}.paper-main .workflow-steps{display:grid;grid-template-columns:repeat(4,minmax(0,1fr));gap:24px;list-style:none;padding:0;margin:0;max-width:none}.paper-main .workflow-steps li{font-family:IBM Plex Sans,sans-serif;margin:0;position:relative;font-size:16px}.workflow-steps span{font:11px var(--mono);color:var(--blue)}.workflow-steps strong{display:block;font-weight:500;line-height:1.35;margin:18px 0 10px;max-width:14ch}.workflow-steps small{display:block;font:13px/1.6 IBM Plex Sans,sans-serif;color:var(--muted)}.workflow-return{display:flex;gap:18px;border-top:1px solid var(--line);margin-top:28px;padding-top:22px}.workflow-return>span{color:var(--blue);font-size:25px}.paper-main .workflow-return p{font:13px/1.8 IBM Plex Sans,sans-serif;max-width:none}.workflow-return strong{font-weight:500}.paper-workflow figcaption{font:12px/1.65 IBM Plex Sans,sans-serif;color:var(--muted);margin-top:20px}.paper-table-scroll .paper-table+p{margin-top:20px}
@media(max-width:650px){.paper-main .workflow-steps{grid-template-columns:1fr 1fr;gap:28px 22px}.workflow-steps strong{margin-top:12px}}

.nb-area{display:block;font:11px/1.7 IBM Plex Sans,Arial,sans-serif;color:#617563;margin-bottom:8px}.nb-area+.nb-type{font-size:9px;letter-spacing:.035em}.nb-methods .nb-entry h3{margin-top:9px}.nb-featured{background:#e9eee5}.nb-featured .nb-entry{grid-template-columns:168px minmax(0,1fr) minmax(240px,340px)}
@media(max-width:800px){.nb-featured .nb-entry{grid-template-columns:1fr 230px}}@media(max-width:550px){.nb-featured .nb-entry{grid-template-columns:1fr}.nb-area{font-size:10px}}
/* Four landscape website cards share the existing page grid. */
.nb-group-libraries .nb-heading{background:#efeee6;padding:18px 32px}
.nb-group-libraries .nb-heading h2{font-size:22px}
.nb-library-grid{display:grid;grid-template-columns:repeat(4,minmax(0,1fr))}
.nb-library{display:block;padding:24px;color:var(--ink);min-width:0}
.nb-library+.nb-library{border-left:1px solid var(--line)}
.nb-library-cover{aspect-ratio:4/3;overflow:hidden;background:#e8e5dc}
.nb-library-cover img{display:block;width:100%;height:100%;object-fit:cover}
.nb-library[data-library="sovietrx"] .nb-library-cover img{object-position:center}
.nb-library-copy{padding-top:20px}
.nb-library h3{display:flex;justify-content:space-between;align-items:baseline;gap:12px;font-size:23px;font-weight:500;line-height:1.2;letter-spacing:-.025em;margin:0 0 10px}
.nb-library h3 span{color:var(--blue);font-size:20px;font-weight:400}
.nb-library p{font-size:14px;line-height:1.55;max-width:31ch;margin:0}
.nb-library-status{display:inline-block;margin-top:13px;font:10px/1.4 var(--mono);color:var(--muted);border:1px solid var(--line);border-radius:3px;padding:4px 7px}
a.nb-library:hover h3{color:var(--blue)}
a.nb-library:focus-visible{outline-offset:-5px}
@media(max-width:1100px){.nb-library{padding:20px}.nb-library h3{font-size:20px}.nb-library p{font-size:13px}}
@media(max-width:900px){.nb-library-grid{grid-template-columns:repeat(2,minmax(0,1fr))}.nb-library:nth-child(3){border-left:0}.nb-library:nth-child(n+3){border-top:1px solid var(--line)}}
@media(max-width:480px){.nb-group-libraries .nb-heading{padding:18px 20px}.nb-library-grid{grid-template-columns:1fr}.nb-library{padding:24px 20px}.nb-library+.nb-library{border-left:0;border-top:1px solid var(--line)}.nb-library h3{font-size:23px}.nb-library p{font-size:14px;max-width:none}}

.nb-library[data-library="pharmakon"] .nb-library-cover img{object-position:center bottom}

/* An understated placeholder for the forthcoming website. */
.nb-library--muted .nb-library-cover{background:#e5e6e6}
.nb-library--muted .nb-library-cover img{filter:grayscale(1);opacity:.45}
.nb-library--muted h3{color:#7b7f83}