- Born
- 10 October 1940
- Country
- United States
- Field
- university teacher, biochemist, physiologist
- In the library
- 1 work, named in 5 passages elsewhere
- Facts from
- Wikidata · Wikipedia · Open Library
Channels and the action potential
Yang and Brackenbury (2013) describe action potentials as firing when a depolarization passes a threshold. They say the fine-tuning of the action potential depends on several key channels and transporters, including voltage-gated sodium channels, voltage-gated potassium channels and the sodium-potassium pump. They cite Hille (1992) with Caldwell and Keynes (1957) for this point1. They also cite Hille (1992) for the diversity of potassium channel types. From that diversity they conclude that each type's share in membrane potential and cell cycle progression is probably context dependent and highly complex2.
Use in later bioelectric work
Baluška and Levin (2016) cite Hille (2001) among the sources for the view that bioelectric systems rest on ion dynamics at membranes. In that view, channels and transporters modify bioelectric fields3. Bonzanni and colleagues (2020) cite Hille (2001) for the definition of the resting membrane potential. It is the voltage at which the net ionic currents across the membrane are zero4. They stress that every cell generates a membrane potential, not only excitable cells. None of these passages disputes Hille's account.
Fine-tuning of APs is tightly regulated by the activities of several key ion channels and transporters, including voltage-gated Na+ channels (VGSCs)
Yang M, Brackenbury WJ, 2013 · Membrane potential and cancer progression · open at passage 3Given the diversity of K+ channel types (Hille, 1992; Miller, 2000; Wang, 2004), their relative contributions to the Vm and Vm-dependent cell cycle progression is probably context-dependent and highly complex.
Yang M, Brackenbury WJ, 2013 · Membrane potential and cancer progression · open at passage 12Most of these bioelectrically active systems are based on ion dynamics at membranes which modify bioelectric fields via activities of ion channels and transporters (Taylor, 1974; Wayne, 1993, 1994; Hille, 2001).
Baluška F, Levin M, 2016 · On Having No Head: Cognition throughout Biological Systems · open at passage 18The resting membrane potential (RMP) represents the voltage at which the net ionic currents across the membrane are zero (Hille, 2001).
Bonzanni M, Payne SL, Adelfio M, Kaplan DL, Levin M, Oudin…, 2020 · Defined extracellular ionic solutions to study and manipulate the cellular… · open at passage 3
