- In the library
- 1 work, named in 4 passages elsewhere
- Facts from
- Open Library
Electrotaxis of cells
Funk (2015) summarises in vitro work showing that many cell types migrate toward the cathode when an applied field is about 0.1 to 10 V/cm. This movement is called electrotaxis1. Funk lists keratinocytes, chondrocytes, rat prostate cancer cells and many epithelial cell types. A 2006 paper by Pullar and co-authors is among the sources given for this list2. The passage does not say what that paper measured. It places the work within a body of studies on field-directed migration.
The 2011 book as reference
Pullar's 2011 book is cited by several authors for the role of membrane voltage in biology. Baluška and Levin cite it for the point that non-neural tissues regulate resting potential, local field potentials and the movement of neurotransmitters among cells, much as the brain does3. Pai and colleagues cite it, with other works, for the role of resting potential regulation in embryogenesis, regeneration and cancer4. In both cases the book supports a general claim rather than one experiment.
Place in the field
Durant and colleagues place Pullar 2011 within a body of work they call classic. The other works named there are by Jaffe, Nuccitelli and Borgens. They say this body of work has since been extended by molecular methods that show trans-epithelial fields, ion currents and resting potential gradients acting as instructive signals for pattern regulation5. The book is used in these papers as a summary of earlier work, not as a source of a disputed claim.
In vitro experiments revealed that many cell types prefer to migrate to the cathode when the externally applied field strengths is around 0.1–10 V/cm (electrotaxis)
Funk RH, 2015 · Endogenous electric fields as guiding cue for cell migration · open at passage 21keratinocytes, chondrocytes, rat prostate cancer cells, and many epithelial cell types (Robinson, 1985; Nishimura et al., 1996; McCaig and Zhao, 1997; Zhao et al., 1997; Djamgoz et al., 2001; Pullar et al., 2006)
Funk RH, 2015 · Endogenous electric fields as guiding cue for cell migration · open at passage 21Analogously to the brain, non-neural tissues continuously regulate resting potential (Vmem) and local field potentials (extracellular electric fields), as well as regulate the movement of neurotransmitters among cells (Pullar, 2011; Bates, 2015).
Baluška F, Levin M, 2016 · On Having No Head: Cognition throughout Biological Systems · open at passage 43Regulation of resting potential (V mem) of a wide variety of cell types plays an important role in embryogenesis, regenerative response, and cancer (Borgens et al. 1977b; McCaig et al. 2005; Blackiston et al. 2009; Pullar 2011
Pai VP, Martyniuk CJ, Echeverri K, Sundelacruz S, Kaplan…, 2016 · Genome-wide analysis reveals conserved transcriptional responses downstream of… · open at passage 6A now classic body of work in this field (Jaffe 1981; Nuccitelli et al. 1986; Borgens et al. 1989; Pullar 2011) has been augmented by modern molecular approaches in the last two decades
Durant F, Lobo D, Hammelman J, Levin M, 2016 · Physiological controls of large-scale patterning in planarian regeneration: a… · open at passage 14
