- In the library
- 3 works, named in 10 passages elsewhere
Review of patterning control
The 2016 review, with Durant as first author, took an engineering view of regeneration. A planarian must recognise damage and direct cells to rebuild what is missing2. Each worm also has a target morphology, and growth stops when it is reached3. The authors argued that gene-level models did not explain how that target is set. They proposed a brain analogy, which predicts that neurotransmitters take part in pattern regulation as well as behaviour4.
Flight and worm numbers
Durant was second author on the 2017 space study. Worms that flew and Earth controls were kept under the same conditions and fed weekly for two more months, then counted. The flown group held slightly fewer worms5. Fragments cut before launch also grew more slowly than the Earth controls. The paper also reports a temperature-matched control set, made after the flight temperature record reached Earth.
How later authors used it
Neuhof, Levin and Rechavi cited the 2016 review for gap junction communication as a somatic memory in planaria, and thanked Durant for comments on their draft6. Levin described "cryptic" worms, whose fragments regrow one head or two at random on each cut, and cited Durant et al. 20177. George and Bates cite the same year for double-headed worms made by brief 8-OH treatment8.
Comparisons of the Procrustes distances between shape groups (Figure 2A, Table 1) showed that the experimentally derived morphologies were closer in shape to the wild-type morphologies they resembled
Emmons-Bell M, Durant F, Hammelman J, Bessonov N, Volpert…, 2015 · Gap Junctional Blockade Stochastically Induces Different Species-Specific Head… · open at passage 12A planarian body must recognize damage, and harness individual cells to rebuild exactly what is missing
Durant F, Lobo D, Hammelman J, Levin M, 2016 · Physiological controls of large-scale patterning in planarian regeneration: a… · open at passage 4each worm has a specific target morphology that, when achieved, causes rapid proliferation and remodeling to cease
Durant F, Lobo D, Hammelman J, Levin M, 2016 · Physiological controls of large-scale patterning in planarian regeneration: a… · open at passage 4The first prediction of the brain analogy is the involvement of neurotransmitters in pattern regulation (not only in the control of behavior).
Durant F, Lobo D, Hammelman J, Levin M, 2016 · Physiological controls of large-scale patterning in planarian regeneration: a… · open at passage 17We observed that the number of worms in the container that had gone to space was slightly less than the number of worms that remained on Earth
Morokuma J, Durant F, Williams KB, Finkelstein JM…, 2017 · Planarian regeneration in space: Persistent anatomical, behavioral, and… · open at passage 18We recently tested the ability of gap junctional communication in somatic cell networks to implement somatic memory in planaria (reviewed in Durant et al., 2016)
Neuhof M, Levin M, Rechavi O, 2016 · Vertically- and horizontally-transmitted memories - the fading boundaries… · open at passage 36Fragments from such “cryptic” worms (Durant et al. 2017) will regenerate as one-headed or two-headed upon each cut, randomly.
Levin M, 2023 · Bioelectric networks: the cognitive glue enabling evolutionary scaling from… · open at passage 40brief treatment of trunk fragments with 8-OH, a gap junction inhibitor, can lead to the regeneration of two heads, creating double-headed animals (Durant et al., 2017).
George LF, Bates EA, 2022 · Mechanisms Underlying Influence of Bioelectricity in Development · open at passage 13
2015
2015 · read
2016
2016 · read
2017
2017 · read