ROB
1923–2008

Robert O. Becker

Later authors cite Robert O. Becker as an early worker on electric fields in regeneration. His 1961 and 1972 studies are listed in the line of work on regeneration and bioelectricity that began in the 1800s4. Funk names him among those who measured fields with single electrodes1. A 1972 rat limb experiment is credited to him2.

Born
31 May 1923
Died
14 May 2008
Country
United States
Field
military physician, university teacher
In the library
2 works, named in 6 passages elsewhere
Facts from
Wikidata · Wikipedia · Open Library
01

Early field measurement

Funk asks why electric fields as a carrier of information were ignored in biology for so long. One reason given is the lack of suitable methods. At first only single electrode measurements were possible, and Funk names DuBois-Reymond, Burr, Becker and Nordenström as working this way1. Funk says the next step was small vibrating, self-calibrating electrodes, developed by Jaffe and Nuccitelli in 1974. These could measure fields and currents at sub-millimetre scale.

02

Rat limb experiments repeated

Tyler lists Becker (1972) among reports that fields in the physiological range led to regeneration of limb tissue in animals that do not normally regenerate, here rats2. Leppik and colleagues later repeated the Becker experiments. In treated rat stumps the bone marrow cavity stayed open. Tyler reports that this possibly let bone marrow progenitor cells form vascularized bone and cartilage centres3. O'Hara-Wright and colleagues cite Becker 1961 and Becker and Spadaro 1972 for the early in vivo regeneration studies4.

SourcesEach quotation was checked word for word against the passage it opens.
  1. because in the beginning only single electrode measurements were possible (DuBois-Reymond, Burr, Becker and NordenströmFunk RH, 2015 · Endogenous electric fields as guiding cue for cell migration · open at passage 7
  2. chicks (Sisken and Fowler, 1981) and rats (Becker, 1972). Repeating the Becker experiments more recently, in ES treated rat limb stumps the bone marrow cavity remained openTyler SEB, 2017 · Nature's Electric Potential: A Systematic Review of the Role of Bioelectricity… · open at passage 21
  3. possibly by causing bone marrow stem/progenitor cells to produce vascularized osseocartilaginous centers (Leppik et al., 2015)Tyler SEB, 2017 · Nature's Electric Potential: A Systematic Review of the Role of Bioelectricity… · open at passage 21
  4. The role of bioelectricity in vivo was first elucidated in the 1800s, with studies on regeneration (Galvani, 1791; Bois-Reymond, 1884; Becker, 1961; Becker and Spadaro, 1972;O'Hara-Wright M, Mobini S, Gonzalez-Cordero A, 2022 · Bioelectric Potential in Next-Generation Organoids: Electrical Stimulation to… · open at passage 4
In the library2 works