Bioelectric cues from piezoelectric materials in stem-cell adhesion and migration

Piezoelectric biomaterials offer a unique strategy for delivering dynamic, self-sustained electrical stimulation to influence stem cell adhesion and migration. By replicating the bioelectric signals inherent in natural regeneration, these advanced scaffolds enhance cellular interactions, facilitate directional migration, and expedite tissue repair across various organ systems. Ongoing advancements in material design, mechanistic understanding, and multimodal integration are expected to address current limitations and propel piezoelectric scaffolds towards clinical application. As research converges at the intersection of materials science, mechanobiology, and regenerative medicine, piezoelectric biomaterials are poised to transform the paradigm of stem cell–based therapies.

The author(s) declare that financial support was received for the research and/or publication of this article. This study was supported by the Development and Clinical Demonstration of an Innovative Internal Fixation System for Femoral Neck Fractures (Grant: 2023YFC2508804), Natural Science Foundation of Sichuan Province (Nos 2025ZNSFSC0342, 2024NSFSC0196 and 2024NSFSC1507), National Key R&D Program of China (No. 2023YFE0105600), Science and Technology Projects of Xizang Autonomous Region (XZ202301ZY0046G and XZ202501ZY0129), Sichuan Science and Technology Program (2023NSFSC1753), Commission of Sichuan Province MedicalScience and Technology Program (24QNMP005), 1.3.5 project for disciplines of excellence, West China Hospital, Sichuan University (2023-309), and Project of Engineering Characteristic Team of Sichuan University.

NC: Writing – original draft, Writing – review and editing. YS: Writing – original draft, Writing – review and editing. RZ: Writing – original draft, Writing – review and editing. XD: Writing – original draft, Writing – review and editing.

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

The author(s) declare that no Generative AI was used in the creation of this manuscript.

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